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Home page > Annuaire > MERLIN Christophe

MERLIN Christophe

Lecturer (PhD, HDR) - at University of Lorraine (France)
Contact : christophe.merlin@univ-lorraine.fr

 

 

Research interests
- Gene transfer in complex natural environments: Antibiotic resistance gene transfer, Dynamics of mobile genetic elements, environmental factors affecting mobile genetic element activities, Effects of antibiotics at sub-inhibitory concentrations.

- Toxicity of Quantum Dot - based nanoparticules towards bacterial cells (in collaboration With Prof. Raphael Schneider): identification of cellular damages, biotransformation of nanoparticlules, disinfection, bacterial stress response.

- Microbial aggregates : Adhesion, physiological activity in biofilms, bacterial dynamics in biofilms.

CV
- 1996: Ph.D. (Microbial Genetics) University of Grenoble (France)
- 1997-1998: postdoctoral position (Microbial Ecology), Michigan State University (USA)
- 2000-2003: postdoctoral position (Bacterial Genomics), University of Edinburgh (UK)
- 2003-2004: postdoctoral position (Bacterial Transcriptomics) , CEA of Cadarache (France)
- since 2005: lecturer (Environmental Microbiology), University of Lorraine (France)


Domain of expertise

Microbiology
Environmental Microbiology
Molecular Biology
Bacterial Genetics

Teaching
Basic microbiology, Environmental microbiology, Bacterial identification, Bacterial biofilms, Gene transfer and Mobile genetic elements, Bacterial genetics, Cell-cell interactions, bacterial communication, Biosensing, Molecular Biology technics and tools.

Responsabilities
- In charge of the LCPME site « Pôle de l’eau »
- Leader of the working group "efficiency of water treatment processes" of the consortium "Zone Atelier Moselle" (http://zam.univ-lorraine.fr/)
- Vice-leader of working group 1 in the NEREUS COST action (http://www.nereus-cost.eu/)

 

Bibliographie

Productions significatives
« Scornec H, Bellanger X, Guilloteau H, Groshenry G, Merlin C. (2017) Inducibility of Tn916 conjugative transfer in Enterococcus faecalis by subinhibitory concentrations of ribosome-targeting antibiotics. J Antimicrob Chemother. 72(10):2722–2728 »

« Berendonk TU, Manaia CM, Merlin C, Fatta-Kassinos D, Cytryn E, Walsh F, Bürgmann H, Sørum H, Norström M, Pons MN, Kreuzinger N, Huovinen P, Stefani S, Schwartz T, Kisand V, Baquero F, Martinez JL. (2015) Tackling antibiotic resistance: the environmental framework. Nat Rev Microbiol. 13:310-317 »

« Bellanger X, Guilloteau H, Bonot S, Merlin C. (2014) Demonstrating plasmid-based horizontal gene transfer in complex environmental matrices: A practical approach for a critical review. Sci Total Environ. 493:872-882. »

«Persistence and dissemination of the multiple-antibiotic-resistance plasmid pB10 in the microbial communities of wastewater sludge microcosms», Merlin C., Bonot S., Courtois S. and Block J.-C., Water Research, 45 (2011), 2897-2905

«Monitoring the dissemination of the broad-host-range plasmid pB10 in sediment microcosms by quantitative PCR», Merlin C. and Bonot S., Appl. Environ. Microbiol., 76 (2010), 378-382

«The exposure of bacteria to CdTe-core quantum dots: the importance of surface chemistry on cytotoxicity», Schneider R., Wolpert C., Guilloteau H., Balan L., Lambert J. and Merlin C., Nanotechnology, 20(22) (2009), :225101

«Why is carbonic anhydrase essential to Escherichia coli ?», Merlin C., Masters M., McAteer S. and Coulson A.., J. Bacteriol., 185(21) (2003), 6415-6424

«Mobile elements as a combination of functional modules», Toussaint A. and Merlin C., Plasmid., 47(1) (2002), 26-35

C.MERLIN publications (2017) - 472 kb