LCPME - UMR 7564


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Home page > Annuaire > EL KIRAT CHATEL Sofiane

EL KIRAT Sofiane

Chargé de Recherche - CNRS
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Current activities
During my career, I have acquired a strong expertise in microbiology and nanobiophysics. I am now combining biological approaches to nanotechnology tools (mostly AFM modalities) to understand how microbial cell adhere on surfaces and form biofilms. Additionally, I use this mechanistic understanding to elaborate innovative bio-inpired strategies for antibiofilm protections.

Research career and fellowships
From 2016 : CNRS Researcher (CR1) Laboratory of Physical Chemistry and Microbiology for the Environment (LCPME), CNRS, University of Lorraine, France.
2015 – 2016 : Postdoc 2 Laboratory of Physical Chemistry and Microbiology for the Environment (LCPME), CNRS, University of Lorraine, France (Advisor: Dr. G. Francius)
2011 – 2015 : Postdoc 1 Nanomicrobio group, Catholic University of Louvain, Belgium (Advisor: Prof. Y. Dufrêne)
2010 – 2011 : Lecturer, Engineering school ENSCBP and Wine Institute ISVV, Bordeaux, France
2007 – 2010 : PhD, Microbiology Immunology (Honours), University of Bordeaux, France. Supervisor: Prof. T. Noël

Skills and competences
Atomic force microscopy applied to biological systems (mapping, adhesion, imaging): single-molecule force spectroscopy, single-cell force spectroscopy, topography.
Microbiology and molecular biology applied to yeast and bacteria
Infrared spectroscopy


2015 : Irish research council (IRC) grant for 2-year postdoc in the Bionano group (Prof. G. Lee), Univ. College of Dublin, Ireland (Award declined for the CNRS position).
2015 : AMOLF Institute grant (FOM) for 1-year postdoc in Nanobiophysics group (Prof. V. Subramaniam), Amsterdam, Netherlands (Award declined for the CNRS position).
2013 : Belgium Society of Microscopy travel grant to attend the AFM-Biomed conference in Shanghai, China.
2009 : Best poster award, Immunity and Pathogenicity Symposium, Bordeaux, France.
2007 – 2010 : French ministry grant for 3 years PhD (MNERT), doctoral school of Microbiology and Immunology, Bordeaux, France.


Major publications (for the complete list please follow the "cv" link)
- El-Kirat-Chatel S, and Dufrêne YF. Nanoscale adhesion forces between the fungal pathogen Candida albicans and macrophages. Nanoscale Horizons, 2016, 1, 69-74.
- Beaussart A, El-Kirat-Chatel S, Sullan RMA, Alsteens D, Herman P, Derclaye S and Dufrêne YF. Quantifying the forces guiding microbial cell adhesion using single-cell force spectroscopy. Nature Protocols, 2014, 9, 1049–1055. Featured protocol.
- El-Kirat-Chatel S, Boyd CD, O’Toole GA and Dufrêne YF. Single-molecule analysis of Pseudomonas fluorescens footprints. ACS Nano, 2014, 8:2, 1690–1698.
- El-Kirat-Chatel S, Beaussart A, Boyd CD, O’Toole GA and Dufrêne YF. Single-cell and single-molecule analysis deciphers the localization, adhesion and mechanics of the biofilm adhesin LapA. ACS Chemical Biology, 2014, 9:2, 485-494.
- El-Kirat-Chatel S, Mil-Homens D, Beaussart A, Fialho AM and Dufrêne YF. Single-molecule atomic force microscopy unravels the binding mechanism of a Burkholderia cenocepacia trimeric autotransporter adhesin. Molecular Microbiology, 2013, 89:4, 649-659.

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